Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Kalpnath, Sujatha Sunil, Priya Jagia, S K Choudhary, R K Bhatnagar and Sanjiv Sharma
All India Institute of Medical Sciences, India
International Centre for Genetic Engineering and Biotechnology, India
Posters & Accepted Abstracts: J Clin Exp Cardiolog
Objective: Genetic susceptibility is an important risk factor for aortic wall degeneration and its leads to thoracic aortic aneurysm and dissection (TAAD). In many patients with TAD, the aorta progressively dilates and ultimately ruptures. The purpose of this study was to determine the single nucleotide polymorphism in 6 genes associated with thoracic aortic aneurysm and dissection patients in Indian population-A case-control study. Methods: Genomic DNA was isolated from blood and aortic wall tissue of 66 patients with degenerative TAAD, and 67 control individuals. Six SNPs: rs819146, rs8003379, rs2853523, rs326118, rs3788205, and rs10757278 were genotyped using TaqMan SNP genotyping assays (Applied Biosystems, Foster City, USA). The data were analyzed using STATA11.0 statistical software. Associations between polymorphisms and disease in tissue, blood and within gender were estimated with odds ratios and their 95% confidence intervals. Results: The T allele frequency for the SNP on 21q22.3, 5��? near gene as rs3788205 (-2174 C/T) was higher in male patients than in male controls (P-0.049). Moreover, with adjustment for traditional cardiovascular risk factors (sex, age, hypertension dyslipidemia diabetes and smoking), the rs3788205 {odd ratio (OD) 0.41, 95% confidence interval (CL) 0.14 to 1.09} polymorphism was found to be an independent susceptibility factor for TAAD in males. Conclusion: Our results suggest that a sequence variant on 21q22.3 is an important susceptibility locus that confers high cross-race risk for development of TAAD in Indian population.
Email: kalpnath3@gmail.com