Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Rahul Mohan
Dayanand Medical College and Hospital, India
ScientificTracks Abstracts-Workshop: J Pharma Care Health Sys
Aim: To compare the efficacy and tolerability of different dosage forms of vitamin D3 in patients with osteoporosis. Materials & Methods: This is an open labeled, randomized, prospective study conducted in the Outpatient Department of Orthopaedics, in Dayanand Medical College and Hospital, Ludhiana. A total of 75 patients were enrolled for the study as per the inclusion criteria. Group 1 (n=25) patients were administered Inj. Vitamin D3 (Cholecalciferol) 6 lac IU Intramuscularly (IM) once a month for 3 months. In Group 2 (n=25), Cap Vitamin D3 60000 IU orally was administered once a week for 5 weeks and in Group 3 (n=25), Vitamin D3 granules 60000 IU (per sachet) orally once a week was given for 5 weeks. In addition, all patients were prescribed oral calcium (500 mg twice a day). The intensity of pain was measured using Visual Analogue Scale (VAS) score. The investigations included serum vitamin D3, serum calcium, serum phosphorus, serum alkaline phosphatase, parathyroid hormone, DEXA scan and X-ray of the affected area. The follow up visits were at 3 months and 6 months. Results: After administration of Vitamin D3 (Cholecalciferol) in all three groups, there was significant improvement in Visual Analogue Scale (VAS) score in all the three groups at 3 and 6 months. There was statistically significant difference in serum calcium level, parathyroid hormone and vitamin D3 level in all the three groups at 3 and 6 months. There was no statistically significant improvement in T-score (DEXA scan) at 6 months. There was osteopenia in all the three groups at 0 months as seen in the X-rays. No improvement in the radiological findings was seen at 3 and 6 months in any of the groups. All three formulations were tolerated equally well. Conclusion: Vitamin D3 does reduce the pain intensity in patients with osteoporosis. Maximum reduction in pain intensity is seen with the oral administration cap/granules of vitamin D3 as compared to the parentral dosage form. The radiological improvement is not evident till 6 months of follow up. This may require further long term studies to substantiate the results.
Rahul Mohan has completed his MBBS from Tribhuvan University, Nepal and doing Postgraduation studies from Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjab.
Email: braj_rahul@yahoo.co.in