ISSN: 2169-0138
+44 1223 790975
Yudy Tjahjono, Bambang Soekardjo, Ratna Megawati Widharna, Wahyu Dewi Tamayanti, Elisabeth Kasih and Caroline
Widya Mandala Catholic University, Indonesia
Posters & Accepted Abstracts: Drug Des
2-(4-chloromethylbenzoyloxy) benzoate has been synthesized as a substitute for acetylsalicylic acid to obtain greater analgesic activity and lower stomach toxicity than acetylsalicylic acid. The 2-(4-chloromethylbenzoyloxy) benzoate was synthesized by using Schotten-Baumann acylation reaction. The analgesic activity was determined by using writhing test on male mice and plantar test on male rats. The acute toxicity tests were performed on Balb/C mice and male Wistar rats under the terms of the toxicity test. The toxic effect was evaluated based on observation of behavior, spinal reflex, central nervous system, urination, defecation and also the number of dead animals, after a single-dose administration of large amounts of compounds. After 14 days, mice and rats were sacrificed and the weight of eight vital organs was measured. The gastric ulcer index of rats was observed. The ED50 of 2-(4-chloromethylbenzoyloxy) benzoate was 11.31 mg/kg on mice and 41.80 mg/kg on rats, whereas the ED50 of acetylsalicylic acid was 20.83 mg/kg on mice and 71.12 mg/kg on rats. The LD50 of 2-(4-chloromethylbenzoyloxy) benzoate was greater than 2000 mg/kg, while the index score of gastric ulcers on rats were 7.00�?±1.15 which it was smaller than acetylsalicylic acid (9.60�?±2.19). This study concluded that 2-(4-chloromethylbenzoyloxy) benzoate was safe to be used as a substitute for acetylsalicylic acid. But the long-term toxicity must be observed with sub-chronic and chronic toxicity tests.
Email: yudy.tjahjono@gmail.com