Journal of Cancer Research and Immuno-Oncology
Open Access

Warburg Effect Peer-review Journals

It is a form of modified cellular metabolism based on aerobic fermentation found in cancer cells, which tend to favor anaerobic glycolysis rather than the oxidative phosphorylation pathway which is the preference of most other cells of the body. Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and together is known as the Warburg Effect. The Warburg Effect has been documented for over 90 years and extensively studied over the past 10 years with thousands of papers reporting to have established either its causes or its functions.