Journal of Cancer Science and Research
Open Access

Myelogenous Leukemia

Chronic myeloid leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by increased and unregulated growth of myeloid cells in the bone marrow and accumulation of these cells in the blood. CML is a clonal bone marrow of stem cell disease in which there is an overgrowth of mature granulocytes (neutrophils, eosinophils and basophils) and their precursors. It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is the most commonly targeted drug known as tyrosine kinase inhibitors (ITKs), which have led to a dramatic improvement in survival rates for most patients. chemotherapy. In western countries, CML accounts for 15-25% of all adult leukemias and 14% of leukemias overall (including the pediatric population, where CML is less common)