Journal of Drug Metabolism & Toxicology
Open Access

Drug Disposition Review Articles

The Drug disposition (absorption, distribution, metabolism, and excretion, known by the acronym ADME) and pharmacokinetics. plays a central role throughout pharmaceutical research and development. These studies aid in the discovery and selection of new chemical entities, support safety assessment, and are critical in defining conditions for safe and effective use in patients. Metabolism is generally accomplished by phase I enzymes that generate more polar  metabolites.