Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Research Article - (2016) Volume 7, Issue 1

The NACHT, LRR and PYD Domains-Containing protein 3 (NLRP3) Inflammasome Mediates Inflammation and Voiding Dysfunction in a Lipopolysaccharide-Induced Rat Model of Cystitis

Francis M Hughes Jr1,2*, James G Kennis2, Melissa N Youssef2, Danielle W Lowe3, Brooke E Shaner4 and J Todd Purves1,2,3,5
1Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC, USA
2Department of Urology, Medical University of South Carolina, Charleston, SC, USA
3Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
4Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA
5Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA
*Corresponding Author: Francis M Hughes Jr, Division of Urology, Department of Surgery, Duke University Medical Center, PO. Box-3831, Durham, NC 27710, USA, Tel: 1-919-668-8361, Fax: 1-919-681-5507 Email:

Abstract