Journal of Clinical & Experimental Dermatology Research
Open Access

Abstract

A Xeroderma Pigmentosum (XP) is a genetically inherited recessive disorder. XP increases risk of skin cancer:

- nonmelanoma---10,000-fold,

- melanomas --- 2,000-fold

- tongue cancers --- 100,000-fold

• Estimated XP incidences in the USA are 1 in 1,000,0001 , 1 in 20,000 in Japan 5 , and approximately 2.3/ million live births in Western Europe 5

• XP has seven different complementation groups (A-G) translated for nucleotide excision DNA repair when exposed and damaged to UV light 1

• Mutation(s) in the XP genes result in a much slower rate of DNA repair

• Some XP patients become severely sunburned after minimal sun exposure with phenotypic expressions of lentigines and progressive neurological degeneration (XPA, XPD, XPG)

• XPC increases the likelihood of developing, earlyonset freckles and skin cancer 1

Author Info

Published: 31-Aug-2020

Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.