Study of Intermolecular Interaction of Hydroxypropyl-β-cyclodextrin Complexes through Phase Diagrams of the Fusion Entropy: Contrast between Nifedipine and Nicardipine Hydrochloride

Yingpeng Li^1,2, Satoru Goto^1,2*, Yohsuke Shimada^1,2, Kazushi Komatsu³, Yuusaku Yokoyama^4,5, Hiroshi Terada^1,2,6 and Kimiko Makino^1,2

¹Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan, E-mail: s.510@rs.tus.ac.jp

²Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan, E-mail: s.510@rs.tus.ac.jp

³Department of Mathematics, Faculty of Science, Kochi Univesrty, 2-5-1 Akebonocho, Kochi, Japan, E-mail: s.510@rs.tus.ac.jp

⁴Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, Japan, E-mail: s.510@rs.tus.ac.jp

⁵The Pharmaceutical Society of Japan, Shibuya 2-12-15, Tokyo, Japan, E-mail: s.510@rs.tus.ac.jp

⁶Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiba-ku, Niigata, Japan, E-mail: s.510@rs.tus.ac.jp

^*Corresponding Author: Satoru Goto, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda Chiba 278-8510, Japan Email: