Prospective Longitudinal Examination of Hyperammonemia during L-Asparaginase Treatment within 24 Hours after Administration in Childhood Lymphoblastic Malignancies

Marios Paulides^1#, Ronny Jung^2#, Martin Chada³, Berthold Lausen⁴, Markus Metzler³ and Thorsten Langer^5*

¹Drug Commission of the German Medical Association, Berlin, Germany

²Pediatrician, practioner, Roth, Germany

³University Hospital for Children and Adolescents, Erlangen, Germany

⁴Professor of Statistics, Department of Mathematical Sciences at University of Essex, UK

⁵University Hospital for Children and Adolescents, Lübeck, Germany

^#Contributed equally to this work

^*Corresponding Author: Dr. Thorsten Langer, University Hospital for Children and Adolescents Loschgestrasse, Ratzeburger Allee 160, 23538 Lübeck, Germany, Tel: +49- 9131-85-33733, Fax: +49-9131-85-36286 Email: