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Prevalence of HIV Setting, Emergency Room Visits for Adults Related to Adverse Drug Reactions
Journal of Pharmacological Reports

Journal of Pharmacological Reports
Open Access

Editorial - (2021) Volume 5, Issue 4

Prevalence of HIV Setting, Emergency Room Visits for Adults Related to Adverse Drug Reactions

Karen Cohen*
 
*Correspondence: Karen Cohen, Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, South Africa, Email:

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Abstract

In South Africa, rapid scale-up of the HIV treatment programme is happening within already overstretched and regularly understaffed health care facilities [1]. While the anti retrovirals currently included in South African guidelines are generally safe, and high adverse drug reactions (ADRs) only occur during a small proportion of patients, the dimensions of the treatment programme means absolutely the ADR burden could also be considerable [2]. Strategies to attenuate preventable harm should form an important a part of such large-scale public health programmes; yet, in our setting, the burden of ADRs generally, and therefore the burden of ADRs attributable to antiretroviral therapy (ART) specifically, remains largely un-known.

In South Africa, rapid scale-up of the HIV treatment programme is happening within already overstretched and regularly understaffed health care facilities. While the anti retrovirals currently included in South African guidelines are generally safe, and high adverse drug reactions (ADRs) only occur during a small proportion of patients, the dimensions of the treatment programme means absolutely the ADR burden could also be considerable. Strategies to attenuate preventable harm should form an important a part of such largescale public health programmes; yet, in our setting, the burden of ADRs generally, and therefore the burden of ADRs attributable to antiretroviral therapy (ART) specifically, remains largely un-known.

The emergency unit (EU) provides an opportune environment in hospital for most patients, and resource limitations may result in even severely ill patients being managed fully in the EU, and not being admitted. Hospital admission has been wont to define an ADR as serious, but we considered that during a resource-limited setting EU presentation can also reflect serious ADRs. We aimed to figure out the proportion of EU presentations at two hospitals in Cape Town, South Africa that were because of ADRs, stratified by HIV status. Secondary objectives were to explain the common ADR manifestations, their preventability, and therefore the drugs most ordinarily implicated, stratified by HIV infection status; to explain the contribution of medicine used in the management of HIV infection and its complications to the burden of ADR-related EU presentations; and to spot factors related to ADR-related EU presentations.

The emergency unit (EU) provides an opportune environment in to hospital for most patients, and resource limitations may result in even severely ill patients being managed fully in the EU, and not being admitted. Hospital admission has been wont to define an ADR as serious, but we considered that during a resource-limited setting EU presentation can also reflect serious ADRs. We aimed to work out the proportion of EU presentations at two hospitals in Cape Town, South Africa that were due to ADRs, stratified by HIV status. Secondary objectives were to explain the common ADR manifestations, their preventability, and therefore the drugs most ordinarily implicated, stratified by HIV infection status; to explain the contribution of medicine used in the management of HIV infection and its complications to the burden of ADR-related EU presentations; and to identify factors associated with ADR-related EU presentations.

We reviewed a random sample of adult medical presentations (about 19 years) from a period of 12 months in two hospitals in Cape Town, South Africa. Groota Schuur Hospital (GSH) is the primary point of reference for primary healthcare facilities in the district and can provide a general level of care by offering tertiary and secondary treatment, and Khayelitsha District Hospital (GDH) could also be a county-level hospital. Tendencies have been previously published in the KDH emergency unit. In 2015, in adults aged 15-49 years, the HIV prevalence in Western Cape Province was 10.0 percent.

Author Info

Karen Cohen*
 
Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, South Africa
 

Citation: Cohen K (2021) Prevalence of HIV Setting, Emergency Room Visits for Adults Related to Adverse Drug Reactions. J Pharma Reports 5: 113.

Received Date: Jul 12, 2021 / Accepted Date: Jul 19, 2021 / Published Date: Jul 26, 2021

Copyright: ©2021 Cohen K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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