Postmenopausal Hyperandrogenism
Journal of Women's Health Care

Journal of Women's Health Care
Open Access

ISSN: 2167-0420


Editorial - (2018) Volume 7, Issue 1

Postmenopausal Hyperandrogenism

Rayhan A Lal and Marina Basina*
Division of Endocrinology, Stanford University School of Medicine, Stanford, California, USA
*Corresponding Author: Marina Basina, Division of Endocrinology and Diabetes, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, USA, Tel: 650) 721-1694 Email:


Hirsutism is a fairly common diagnosis affecting 10% of women [1]. Mild symptoms are not always brought to medical attention, but severe cases, especially in menopause that are associated with hyperandrogenism, require evaluation and treatment. We present a case of postmenopausal hirsutism to demonstrate the diagnostic and therapeutic challenges seen in practice. A 55 year-old postmenopausal woman with history of multi nodular goiter, autoimmune hepatitis, lupus erythematosus panniculitis, diabetes and acid reflux presents with restlessness, increased libido, hair loss, worsening hirsutism, and 25-pound weight loss over 2 months. Medications include azathioprine, metformin, lisinopril, and omeprazole. Physical examination revealed BMI of 34 kg/m2, severe hirsutism (Ferriman- Gallwey score of 18), receding hairline, goiter, prior scarring from abdominal procedures and normal external genitalia without clitoromegaly. Labs included TSH 1.05 (normal 0.5-4.5), hemoglobin A1c of 6.1% (normal <5.7), LH 29.8 mIU/mL (normal 20-70), FSH 38.5 mIU/mL (normal 30-120), total testosterone 94.7 ng/dL (normal 7-40), free testosterone 2.2 ng/dL (normal <1), estradiol 28.5 pg/mL (normal <20), DHEA-S 25.2 μg/dL (normal 15-200), cortisol 7.1 μg/dL (normal 7-20) and ACTH 15 pg/mL (10-60 pg/mL). Screening tests for occult Cushing’s syndrome and pheochromoctyoma were negative.

CT scan of the abdomen and pelvis demonstrated normal pelvic structures but revealed a 1 cm left adrenal adenoma (Figure 1) confirmed on adrenal MRI.


Figure 1: CT demonstrating left adrenal mass (arrow).

Trans vaginal/Trans abdominal ultrasound allowed only partial visualization of the left ovary. Due to the small size of adrenal nodule and peri-menopausal timing of the onset of the symptoms, ovarian pathology was suspected. Laparoscopic bilateral salpingooophorectomy was performed. It revealed grossly normal ovaries (Figure 2) but histology confirmed bilateral ovarian hyperthecosis. Testosterone normalized following surgery and symptoms resolved.


Figure 2: Laparoscopic view of normal-appearing bilateral ovaries.

Physiologic changes of normal menopause consist of progressive follicular atresia with decreased secretion of inhibin B, which inhibits FSH. The increased FSH concentration maintains ovarian production of estrogen preceding menopause. Testosterone production is preserved and some is converted to estrogen by aromatase. As a compensation for falling estrogen, Gonadotropin Releasing Hormone (GnRH) rises resulting in elevation of both LH and FSH. In early menopause the ovarian theca cells continue to produce androstenedione and testosterone. Adrenal androgen production is preserved throughout this process [2].

Additionally, sex hormone binding globulins are reduced increasing the free bioactive androgens [3]. The result is an overall increase in the ratio of androgens to estrogen that may result in mild hirsutism. Rapid progression to severe hirsutism, alopecia or acne is suggestive of pathology [4]. Benign hyperandrogenism is suspected when total testosterone measures of 40-140 ng/dL [4,5]. Insulin resistance and polycystic ovarian syndrome are the most common causes of female hyperandrogenism. Elevated insulin levels induce theca cells to produce androgens and act as a co-gonadotropin augmenting LH activity [6].

Hyperthecosis is another gonadotropin-dependent ovarian hyperandrogenism where in luteinized theca cells throughout the ovarian stroma over express testosterone [7]. Congenital adrenal hy






perplasia involves enzyme deficiencies producing an ACTHdependent adrenal hyperandrogenism due to shunting of steroid precursors to androgens [8]. ACTH excess from Cushing’s disease stimulates adrenal androgen production. Another cause is accidental or intentional exposure to androgenic medications or supplements.

When virilization occurs with clitoromegaly, male-pattern baldness, and deepening of the voice, malignancy must be excluded [5]. A review of androgen-secreting adrenocortical tumors reported free testosterone >6.85 pg/mL had the best sensitivity (82%) and specificity (97%) but there is clinical overlap [9]. Adrenal tumors are frequently gonadotropin-independent, although exceptions exist [10]. Ovarian malignancy also tends to be gonadotropin-independent, but basal hormone measures are not sufficient for diagnosis.

Few studies have explored the best method for evaluating postmenopausal hyperandrogenism [4,5]. Several others have reported postmenopausal hyperthecosis in the presence of adrenal incidentaloma. Our case is an example where algorithms would incorrectly suggest adrenal pathology. However, the prevalence of disease favors an ovarian over adrenal androgen source. GnRH agonist testing cannot differentiate adrenal and ovarian etiologies; dexamethasone suppression testing may help [10]. It is crucial for providers to differentiate between hormonal changes of normal aging and pathological cause of hyperandrogenism.


  1. Morreale HF, Carmina E, Dewailly D, Gambineri A, Kelestimur F, et al. (2012) Epidemiology, diagnosis and management of hirsutism: A consensus statement by the androgen excess and polycystic ovary syndrome society. Hum Reprod Update 18: 146-170.
  2. Davis SR, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, et al. (2015) Menopause. Nat Rev Dis Primers 1: 15004.
  3. Gershagen S, Doeberl A, Jeppsson S, Rannevik G (1989) Decreasing serum levels of sex hormone-binding globulin around the menopause and temporary relation to changing levels of ovarian steroids, as demonstrated in a longitudinal study. Fertil Steril 51: 616-621.
  4. Rothman MS, Wierman ME (2011) How should postmenopausal androgen excess be evaluated? Clin Endocrinol 75: 160-164.
  5. Alpanes M, Casbas JM, Sanchez J, Pian H, Morreale HF (2012) Management of postmenopausal virilization. J Clin Endocrinol Metab 97: 2584-2588.
  6. Nestler JE, Jakubowicz DJ, DeVargas AF, Brik C, Quintero N, et al. (1998) Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositoglycan mediators as the signal transduction system. J Clin Endocrinol Metab 83: 2001-2005.
  7. Goldman JM, Kapadia LJ (1991) Virilization in a postmenopausal woman due to ovarian stromal hyperthecosis. Postgrad Med J 67: 304-306.
  8. Pang S (1997) Congenital adrenal hyperplasia. Baillieres Clin Obstet Gynaecol 11: 281-306.
  9. Alva CB, Lepage G, Viallon V, Groussin L, Dugue MA, et al. (2008) Sex steroids in androgen-secreting adrenocortical tumors: Clinical and hormonal features in comparison with non-tumoral causes of androgen excess. Eur J Endocrinol 159: 641-647.
  10. Ahmad I, Anawalt BD (2017) High concentrations of LH cause virilization in a postmenopausal woman. Clin Case Rep 5: 225-228.
Citation: Lal RA, Basina M (2018) Postmenopausal Hyperandrogenism. J Women's Health Care 7: e132.

Copyright: © 2018 Lal RA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.