Pharmaceutical Analytical Chemistry: Open Access
Open Access
ISSN: 2471-2698
ISSN: 2471-2698
Short Communication - (2020)Volume 5, Issue 3
Chitin and its derivative were investigated as novel direct compression (DC) excipients for immediate and controlled release applications. In the former, roller compaction technology was employed in a specific manner to convert the low bulk density, poor flowability and low compactibility of chitin powder into a DC excipient. In the latter, a combination of low molecular weight chitosan (LCS) with xanthan gum was found to provide the basis for controlled release preparations. The novel excipients were characterized using XRPD and FTIR tests. Compressibility and compactibility of the powders were examined thereafter using flow indices, Heckel and Kawakita analysis, and force-displacement curve. The novel excipients showed improvement in powder flow, high resistance to compression force, and high extent of plastic deformation. This work further elaborated on the role of LCS in the enhancement of powder compressibility and compacts strengths when mixed at an optimum mass content with the highly fragmenting xanthan gum. Dissolution profiles of metronidazole and metoprolol succinate tablets comprising the novel excipients confirmed their suitability in immediate and controlled release applications.
Abu Fara D. has completed his PhD from McGill University, Canada. He is associate professor at the Chemical Engineering Dept., University of Jordan, Jordan. His current research interest is in the field of the application of natural polymers in the pharmaceutical industry.
Published: 21-Sep-2020 , DOI: 10.35248/2471-2698.20.5.151
Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.