Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609

Research Article - (2010) Volume 1, Issue 1

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Metabolites in Safety Testing: Issues and Approaches to the Safety Evaluation of Human Metabolites in a Drug that is Extensively Metabolized

Patrizia Griffini1, Alexander D. James2, Andrew D. Roberts3 and Mario Pellegatti4*
1Aptuit, Medicine Research Centre, Via Fleming 4, 37135 Verona, Italy
2Novartis Pharma AG, DMPK Biotransformation, Fabrikstrasse 14, CH4002, Basel, Switzerland
3GlaxoSmithKline, Ware, Hertfordshire SG12 0DP, United Kingdom
4Drug Metabolism and Pharmacokinetics Department, GlaxoSmithKline, Via Fleming 2, 37135 Verona, Italy
*Corresponding Author: Mario Pellegatti, Drug Metabolism and Pharmacokinetics Department, GlaxoSmithKline, Via Fleming 2, 37135 Verona, Italy, Tel: (+39) 045-8218403, Fax: (+39) 045-9218061 Email:

Abstract