Loss of Cellular Immune Response against Shared Mycobacterial Antigens is Associated with Active Pulmonary Tuberculosis in Adults

Ashwini Shete^1*, Vishwanath Pujari², Poonam Kadam¹, Shubhangi Bichare¹, Narayan Panchal³, Jyoti Pawar³, Shraddha Bapat³, Raman Gangakhedkar^3,4, Tilak Dhamgaye⁵ and Madhuri Thakar¹

¹Department of Immunology, National AIDS Research Institute, Pune, India

²Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals, Mumbai, India

³Department of Clinical Sciences, National AIDS Research Institute, Pune, India

⁴Indian Council of Medical Research, New Delhi, India

⁵JN Medical College, Wardha, Nagpur, India

^*Corresponding Author: Ashwini Shete, Department of Immunology, National AIDS Research Institute, 73, G Block, MIDC, Bhosari,Pune- 411026, India, Tel: 91 2027331200 Email:

Keywords: Pulmonary tuberculosis; Latent infection; Household contacts; Re-infection; Reactivation; Immune responses; Shared antigens

Introduction