Research Article - (2014) Volume 5, Issue 4
Increased IRAK-4 Kinase Activity in Alzheimer’s Disease; IRAK-1/4 Inhibitor I Prevents Pro-inflammatory Cytokine Secretion but not the Uptake of Amyloid Beta by Primary Human Glia
- Jeroen J.M. Hoozemans1*, Elise S. Van Haastert1, Sandra D. Mulder2, Henrietta M. Nielsen1,2,4, Robert Veerhuis2,3, Rob Ruijtenbeek5, Annemieke J.M. Rozemuller1, Riet Hilhorst5 and Saskia M. Van Der Vies1
- 1Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
- 2Department of Clinical Chemistry, Neurology and Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
- 3Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
- 4Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
- 5PamGene International BV, ‘s Hertogenbosch, The Netherlands
*Corresponding Author:
Jeroen J.M. Hoozemans, Department of Pathology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands, Tel: 31-20-4444910, Fax: 31-20-4442964
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