Impaired Autophagy in Retinal Pigment Epithelial Cells Induced from iPS Cells obtained from a Patient with Sialidosis

Odontuya Davaadorj^1,3, Hisako Akatsuka^1,2, Yoshiki Yamaguchi¹, Chisa Okada⁴, Masatoshi Ito⁴, Nahoko Fukunishi⁴, Yoshiki Sekijima⁵, Hideki Ohnota⁶, Kenji Kawai³, Takahiro Suzuki³, Takehito Sato^1* and Yasuyuki Suzuki³

¹Department of Host Defense Mechanism, School of Medicine, Tokai University, Kanagawa, Japan, E-mail: takehito@is.icc.u-tokai.ac.jp

²Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, School of Medicine, Tokai University, Kanagawa, Japan, E-mail: takehito@is.icc.u-tokai.ac.jp

³Department of Ophthalmology, School of Medicine, Tokai University, Kanagawa, Japan, E-mail: takehito@is.icc.u-tokai.ac.jp

⁴Support Center for Medical Research and Education, Tokai University, Kanagawa, Japan, E-mail: takehito@is.icc.u-tokai.ac.jp

⁵Department of Medicine and Neurology and Rheumatology, School of Medicine, Shinshu University, Nagano, Japan, E-mail: takehito@is.icc.u-tokai.ac.jp

⁶Department of Drug Discovery Science, School of Medicine, Shinshu University, Nagano, Japan, E-mail: takehito@is.icc.u-tokai.ac.jp

^*Corresponding Author: Takehito Sato, Department of Host Defense Mechanism, School of Medicine, Tokai University, Kanagawa, Japan, Tel: +81-463-93-1121 Exn. 2593, Fax: +81-463-94-2976 Email: