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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Clinical image - (2020)Volume 11, Issue 5

Doughnut Cells or Ring Neutrophil by Immunofluorescence

Suelen Brito Nascimento1, Miguel Augusto Martins Pereira2* and Hye Chung Kang3
 
*Correspondence: Miguel Augusto Martins Pereira, Medical School, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil, Email:

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Clinical Image

The presence of ring-shaped nuclei neutrophils or doughnut cells (Figure 1) is well known in rats and mousesgranulopoiesis, and it was later described in humans. Ring and/or hyposegmented neutrophils are already well-known findings in leukemia patients, [1] megaloblastic anemia and myeloproliferative diseases [2,3]. An occasional occurrence is also present in patients with myelodysplastic syndrome (MDS) or chronic granulocytic leukemia (CGL). Besides there are still reports on infectious mononucleosis, Chagas disease, [4] and lymphoproliferative disorders (multiple myeloma and monoclonal gammopathy of undetermined significance) or even in healthy individuals [5,6]. Thus, this peculiar morphological presentation can be considered a nonspecific finding of several hematological diseases. Hence, we present not only the hematoxylin and eosin stain representation but a unique point of view (by immunofluorescence) of a ring-shaped nuclei neutrophil in a years old male patient with multiple myeloma suspicion.

clinical-cellular-immunology

Figure 1: Flow Diagram.

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Declaration of funding

This study had no funding resources.

Adherence to national and international regulations

Not applicable.

Authors’contributions

All authors read and approved the final manuscript.

Acknowledgment

None.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Ethics approval and consent to participate

Written informed consent was obtained from the patient for participation in the study.

Consent for publication

The authors declare that they have no competing interests.

Competing interests

The authors declare that they have no competing interests.

References

  1. Kanoh T, Saigo K, Yamagishi M. Neutrophils with ring-shaped nuclei in chronic neutrophilic leukemia. Am J ClinPathol. 1986;86(6):748-751.
  2. Langenhuijsen MC. Neutrophils with ring-shaped nuclei in myeloproliferative disease. Brit J Haematol. 1984;58(2):227-230.
  3. Lee S, Hahn J, Park S,Hasler P. Ring neutrophils and hyposegmented cells in hematologic diseases. Korean J Hematol. 1997;32(1):41-47.
  4. Cabral H. Neutrophils with ring-shaped nuclei in human chagas’ disease. Brit JHaematol. 1987;67(1),118-119.
  5. Kanoh T. Ring neutrophils in plasma cell dyscrasia. Arch Pathol Lab Med. 1991;115(2):178-80.
  6. Cabral H, Robert G. Ring-shaped nuclei in human neutrophilic leukocytes of healthy individuals: Evidence of their occurrence and characteristics. Am J Hematol. 1989;30(4):259-60.

Author Info

Suelen Brito Nascimento1, Miguel Augusto Martins Pereira2* and Hye Chung Kang3
 
1Department of General Pathology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil
2Medical School, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil
3Department of Pathology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil
 

Citation: Nascimento SB, Pereira MAM, Kang HC (2020) Doughnut Cells or Ring Neutrophil by Immunofluorescence. J Clin Cell Immunol. 11:597. DOI: 10.35248/2155-9899.20.11:597.

Received: 27-Aug-2020 Accepted: 10-Sep-2020 Published: 17-Sep-2020 , DOI: 10.35248/2155-9899.20.11.597

Copyright: © 2020 Nascimento SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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