Differential Requirements for Protein Kinase C-Theta at The Immunological Synapse of Effector Versus Regulatory T Cells and Their Clinical Implications

Noah Isakov^*

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of Negev, P.O.B. 653, Beer Sheva 84105, Israel

^*Corresponding Author: Noah Isakov, The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of Negev, P.O.B. 653, Beer Sheva 84105, Israel, Tel: 972-8-647-7267, Fax: 972-8-647-7626 Email:

Keywords: Protein kinase C θ; Immunological synapse; Regulatory T cells; Effector T cells; Signal transduction; T cell activation

Introduction