Detection and Identification of Reactive Drug Metabolites Leading to Idiosyncratic Toxicity: Lapatinib as a Case Example

Rayane Mohamed^1,2, Flavia Storelli², Jonathan Sidibe¹, Nasim Bararpour¹, Jules Desmeules^2,3, Marc Ausburger¹, Youssef Daali^2,3* and A Thomas^1,4

¹Unit of Toxicology, CURML, Geneva University Hospitals, Lausanne University Hospital, Ch. de la Vulliette 4, 1000 Lausanne 25,, Switzerland

²Clinical Pharmacology and Toxicology Service, Anesthesiology, Pharmacology and Intensive Care Department, Geneva University Hospitals, Geneva, Switzerland

³Faculty of Medicine, University of Geneva, Switzerland

⁴Faculty of Biology and Medicine, University of Lausanne, Ch. de la Vulliette 4, 1000 Lausanne 25, Switzerland

^*Corresponding Author: Youssef Daali, Faculty of Medicine, Hopitaux Universitaires De Geneve APSI Rue Gabrielle-Perret-Gentil 4 Geneva, 1205, Switzerland Email: