Comparison of Metabolism of Donepezil in Rat, Mini-Pig and Human, Following Oral and Transdermal Administration, and in an In Vitro Model of Human Epidermis

S. R. Meier-Davis^1*, R. Murgasova², C. Toole³, F. M. Arjmand¹, L. Diehl⁴, B. Cayme¹, J. Wen¹, J. Shudo¹ and T. Nagata¹

¹Teikoku Pharma USA, Inc., USA

²Charles River Preclinical Services, Montreal, Senneville (Quebec), Canada

³CeeTox, Inc., Kalamazoo, Michigan, USA

⁴Charles River Laboratories, Spencerville, OH, USA

^*Corresponding Author: S. R. Meier-Davis, 1718 Ringwood Avenue, San Jose, CA 95131, Canada, Tel: +408-501-1829, Fax: +408-501-1929 Email: