Comparative Study of Prions in Iatrogenic and Sporadic Creutzfeldt-Jakob Disease

Mai Abouelsaad¹, Wen-Quan Zou^1,7,8,9*, Qingzhong Kong^1,7, Pierluigi Gambetti¹, James W. Ironside⁶, Paul Brown⁵, Gong-Xian Wang⁹, Manuel Camacho Martinez¹, Dimitris Gazgalis¹, Xiangzhu Xiao^1#, Liang Zeng^1,9, Emmanuelle Uro-Coste^3,4, Marie-Bernadette Delisle^3,4, Jacqueline Mikol², Ignazio Cali^1,10, Liuting Qing¹ and Jue Yuan^1#

¹Department of Pathology and National Prion Disease, Pathology Surveillance Center, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA

²Department of Pathology, Hôpital Lariboisière, 2 rue Ambroise Paré, Paris, France

³Department of Pathology, Rangueil University Hospital, avenue Jean Poulhes, TSA 50032, 31059 Toulouse Cedex 9, France

⁴INSERM U858, I2MR, Team 15, BP 84225, 31432 Toulouse Cedex 4, France

⁵Commissariat à 1’Énergie Atomique (CEA), Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France

⁶National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital Edinburgh, EH4 2XU, United Kingdom

⁷Department of Neurology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA

⁸National Center for Regenerative Medicine, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA

⁹The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, The People’s Republic of China

¹⁰Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy

^#Contributed equally to this work

^*Corresponding Author: Wen-Quan Zou, M.D., Ph.D., Institute of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH 44106, USA, Tel: +1-216-368-8993, Fax: +1-216-368-8993 Email: