Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Research Article - (2014) Volume 5, Issue 4

Comparative Study of Prions in Iatrogenic and Sporadic Creutzfeldt-Jakob Disease

Mai Abouelsaad1, Wen-Quan Zou1,7,8,9*, Qingzhong Kong1,7, Pierluigi Gambetti1, James W. Ironside6, Paul Brown5, Gong-Xian Wang9, Manuel Camacho Martinez1, Dimitris Gazgalis1, Xiangzhu Xiao1#, Liang Zeng1,9, Emmanuelle Uro-Coste3,4, Marie-Bernadette Delisle3,4, Jacqueline Mikol2, Ignazio Cali1,10, Liuting Qing1 and Jue Yuan1#
1Department of Pathology and National Prion Disease, Pathology Surveillance Center, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
2Department of Pathology, Hôpital Lariboisière, 2 rue Ambroise Paré, Paris, France
3Department of Pathology, Rangueil University Hospital, avenue Jean Poulhes, TSA 50032, 31059 Toulouse Cedex 9, France
4INSERM U858, I2MR, Team 15, BP 84225, 31432 Toulouse Cedex 4, France
5Commissariat à 1’Énergie Atomique (CEA), Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses, France
6National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital Edinburgh, EH4 2XU, United Kingdom
7Department of Neurology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
8National Center for Regenerative Medicine, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
9The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, The People’s Republic of China
10Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
#Contributed equally to this work
*Corresponding Author: Wen-Quan Zou, M.D., Ph.D., Institute of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH 44106, USA, Tel: +1-216-368-8993, Fax: +1-216-368-8993 Email:

Abstract