Clinical Significance of WT1 mRNA Levels in Japanese Acute Lymphoblastic Leukemia Patients

Ken Ishiyama¹⁵, Keizo Horibe²⁹, Haruo Sugiyama²⁸, Katsuyoshi Koh²⁷, Tomoki Naoe²⁶, Kiyotoshi Imai²⁵, Yoshihide Miyazaki²⁴, Yoshinobu Kanda²³, Kensuke Usuki²², Atsuko Mugitani²¹, Yasunori Ueda²⁰, Hiroko Tsunemine¹⁹, Kunio Kitamura¹⁸, Michihiro Hidaka¹⁷, Kinuko Mitani¹⁶, Yoshiko Hashii^1,29*, Naoyuki Uchida¹⁴, Tomoko Hata¹³, Takafumi Nakao¹², Masahiro Hirayama¹¹, Yuhki Koga¹⁰, Hidefumi Hiramatsu⁹, Arata Watanabe⁸, Shosuke Sunami⁷, Takashi Kaneko⁶, Masue Imaizumi⁵, Koji Kato⁴, Kenichiro Watanabe³ and Yoshiyuki Kosaka²

¹Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan

²Department of Hematology and Oncology, Children’s Cancer Center, Hyogo Prefectural Kobe Children’s Hospital, Hyogo, Japan

³Department of Hematology and Oncology, Shizuoka Children’s Hospital, Shizuoka, Japan

⁴Department of Pediatrics, Japanese Red Cross Nagoya Daiichi Hospital, Aichi, Japan

⁵Department of Hematology and Oncology, Miyagi Children’s Hospital, Miyagi, Japan

⁶Department of Hematology/Oncology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan

⁷Department of Pediatrics, Japanese Red Cross Narita Hospital, Chiba, Japan

⁸Department of Pediatrics, Nakadori General Hospital, Akita, Japan

⁹Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

¹⁰Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

¹¹Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan

¹²Department of Hematology, Osaka City General Hospital, Osaka, Japan

¹³Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

¹⁴Department of Hematology, Toranomon Hospital, Tokyo, Japan

¹⁵Department of Hematology, Kanazawa University Hospital, Ishikawa, Japan

¹⁶Department of Hematology and Oncology, Dokkyo Medical University, School of Medicine, Tochigi, Japan

¹⁷Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan

¹⁸Division of Hematology, Ichinomiya Municipal Hospital, Aichi, Japan

¹⁹Department of Hematology, Shinko Hospital, Hyogo, Japan

²⁰Department of Hematology/Oncology, Transfusion and Haemapheresis Center, Kurashiki Central Hospital, Okayama, Japan

²¹Department of Hematology, Seichokai Fuchu Hospital, Osaka, Japan

²²Department of Hematology, NTT Medical Center, Tokyo, Japan

²³Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan

²⁴Diagnostic Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan

²⁵Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan

²⁶National Hospital Organization Nagoya Medical Center, Aichi, Japan

²⁷Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama, Japan

²⁸Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan

²⁹Clinical Research Center, National Hospital Organization Nagoya Medical Center, Aichi, Japan

^*Corresponding Author: Yoshiko Hashii, MD, PhD, Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, Tel: +81-6-6879-3932, Fax: +81-6-6879-3939 Email: