Department of Cell Biology and Anatomy
University of South Carolina School of Medicine, SC 29209, Colombia
I was recruited as a tenure track assistant professor to the University of South Carolina School of Medicine in 2007, I established a novel research effort regarding the molecular mechanism of heart failure with a specific focus on redox signaling. Over the past 8 years, my laboratory demonstrated that Nrf2, a key transcriptional factor of antioxidant defense is a negative regulator of cardiac maladaptive remodeling and dysfunction. This research has indicated that targeting Nrf2 holds the promise for the treatment of cardiac disease. In addition, my laboratory has demonstrated that deubiquitinating enzymes (DUBs) such as CYLD serve as a novel group of regulators in cardiac remodeling and dysfunction.
Cardiac maladaptive remodeling and dysfunction