Professor, Department of Physiology, School of Medicine
University of Puerto Rico, USA
Sabzali Javadov received his M.D. degree in medical biochemistry from the Russian Medical University (1983), a Ph.D. in biochemistry and cardiology from the Cardiology Research Center, Moscow (1986) and a D.Sc. in experimental cardiology from the Moscow State University (1993). He had postdoctoral training in biochemistry and experimental cardiology at the Magdeburg Medical Academy in Germany, the National Institute of Cardiology in Hungary and the University of Bristol, England among others. He won the Royal Society award three times to conduct collaborative research in the Department of Biochemistry of the University of Bristol, UK. Since 2003, Dr. Javadov worked as a Research Scientist at the University of Western Ontario, Canada. At the present time he is Associate Professor in the Department of Physiology at the School of Medicine, University of Puerto Rico.
Dr. Javadov elucidates the role of mitochondrial permeability transition pores (PTP), the non-specific pathological channels which are created in the inner mitochondrial membrane in response to oxidative stress, in cardiac dysfunction. His group is currently investigating a regulatory role of the AMPK/PGC-1α pathway in PTP formation during ischemia/reperfusion and heart failure. In addition, his lab examines the relationship between mitochondrial protein acetylation and PTP opening in response to oxidative or hormonal stress to further clarify the contribution of mitochondrial SIRT3 to PTP-mediated cell dysfunction. A main goal of these studies is to develop different pharmacological and conditional strategies targeting the PTP to further inhibit mitochondria-mediated cardiac dysfunction in ischemia/reperfusion and heart failure.