Associate Professor, Molecular Biology and Immunology
University of North Texas, USA
Rajendra Sharma is a Research Associate Professor in Molecular Biology and Immunology, University of North Texas. He he was a Research fellow, Rajasthan University, Jaipur, India (1975-1979). Research Associate, All India Institute of Medical Sciences, New Delhi (1980-1981). Post-doctoral fellow (1989-1991). Suptdg. Chemist at KDMIPE, Dehradun, India ( April 1991- March 2000). Visiting Scientist at UTMB, Galveston, TX (April 2000-Sept. 2003). Suptdg, Chemist at KDMIPE, Dehradun, India (Oct 2003- Aug.2005).
1. To investigate the detoxification mechanisms of xeno- and endo-biotics by glutathione linked phase II enzymes particularly GSTs as well as their role in protection against oxidative stress.
2. Role of 4-HNE in cellular signaling related to apoptosis, cell proliferation and transformation and modulation of its intracellular concentration by coordinated action of GSTs and RLIP76.
3. Chemoprevention of Cancer by natural products: These studies are focused on the role of lipid peroxidation in the mechanisms of cancer prevention and cell killing by sulforaphane, curcumin and Withaferin A.