Endocrinology & Metabolic Syndrome
Open Access

Oscar M. Pello

Biography

After obtaining my degree in Biochemistry (July 2001; Oviedo University, Spain) I worked at the Centro de Investigaciones Biológicas (CSIC; Madrid, Spain) where I acquired basic knowledge on myeloid cell biology and routine techniques (Sep. 2001 - Dec 2002). Then I obtained a fellowship from the Spanish Ministry of Science and Technology to do my Doctoral Thesis at the Centro Nacional de Biotecnología (CSIC; Madrid, Spain) on a specific feature of myeloid cells, such as the pattern of expression and functionality of chemokine receptors (Jan. 2003 – Feb. 2007). Later, I was awarded by the Theleton Institute for gene therapy with a postdoctoral fellowship (March 2007 – Aug. 2008) to improve my knowledge in lentiviral platforms used on myeloid cells in Prof. Luigi Naldini´s lab (Ospedale San Raffaelle, Milan, Italy) who is considered one of the best specialists in the field. I continued with a postdoctoral fellowship from Alfonso Martin Escudero foundation to directly apply our new developed lentiviral vectors and protocols optimized for myeloid cells on the study and genetic modification of macrophages associated to pathologies, specially tumors, at Istituto Clinico Humanitas (Sep. 2008 – Sep. 2010; Milan, Italy). During this two years fellowship I identified the c-Myc transcription factor as one of the main controllers of the phenomenon of macrophage polarization. During my postdoc in Milan, I performed a short-stay in Dr. Rodrigo Mora’s lab at Massachusetts Harvard Medical School to study the possible expression of c-Myc in different myeloid cells such as gut-associated dendritic cells (granted by the European macrophage and dendritic cell society). In October 2010, I was awarded with a contract from the Spanish Ministry of Science and Innovation (Juan de la Cierva programme) to continue my work in the field of macrophages associated to cardiovascular diseases at the Centro National de Investigaciones Cardiovasculares (CNIC; Madrid, Spain).

Research Interest

Immunology
Myeloid Cells
Monocyte recruitmen to normal and pathological tissues
Macrophage differentiation
Macrophage activation / polarization
Macrophage subtypes during embryo development
Macrophages subtypes and metabolism / obesity
Macrophage subtypes and atherosclerosis