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Associate Professor, Department of Biochemistry and Biophysics
Second University of Naples, Italy
Professor Michele Caraglia Currently is working as Associate Professor in Biohemistry at the Department of Biochemistry and Biophysics of the Second University of Naples. He is serving as an editorial member of several reputed journals like Current Cancer Drug Targets Cancer Biology and Therapy International Journal of Oncology Cell Biology International Recent Patents on Anticancer Drug Discovery. He is author of 2 international patents and is a member of American Association for Cancer Research and is in the Managing Board of the Italian Association for Cell Cultures AICC.
He has studied the escape mechanisms from the anti-proliferative and apoptotic effects induced by Interferon alpha in human cancer cells derived from epidermoid head and neck and lung cancers. He has found that these cells overcome the apoptosis through the induction of an EGF-Ras-dependent pathway that can be antagonized through the use of farnesyltransferase inhbitors potentiate the anti-cancer acitvity of the former in prostate and head and neck cancer cells.