Institute of Biochemistry and Molecular Biology
National Yang Ming University, Taiwan
Dr. Jean-Cheng Kuo is one of the scientists that focus on the topic of the mechanosensitivity of integrin-based adhesion, which allows cells to translate physical cues from their environment (shear force in endothelia, tumor stiffness in cancer cells, ECM organization in fibroblasts) into biochemical cues that control cell behavior, differentiation, and death. She established a systematic method with a proteomics approach and microscopy-based technology and used this method to determine how the protein composition of integrin-based focal adhesions are modulated by myosin II-generated internal force and transduced biochemical signals to drive cell migration. Currently, Dr. Kuo’s group is interested in understanding how the signals of integrin-based focal adhesions regulate osteogenic differentiation in mesenchymal stem cells and cancer metastasis.
Cell migration, cell adhesion, cytoskeleton, stem cells, cancer