Anil Kumar Jain
Department of Pharmaceutical Sciences, School of Pharmacy
University of Colorado, USA
I received my PhD degree in reproductive physiology in 2008 from Banaras Hindu University (BHU), India and a Master degree in Biotechnology from Agra University, India in 2002. After completing my PhD degree, I moved USA to continue my research work and joined School of Pharmacy, University of Colorado Denver as a Visiting Research Associate in Cancer and Skin Biology.
(a) Numerous genes have been identified as essential components of follicle rupture but specific roles of the genes in follicle rupture remain largely unknown. For example, while progesterone receptors (PR) and cyclooxygenase-2 (COX-2) are the two most extensively studied LH-induced genes in the ovary and are required for follicle rupture as was shown by the lack of follicle rupture (and the presence of unruptured follicles) in their respective knockout mouse ovaries. However, the mechanistic roles of these genes in the follicle rupture is not known. My interest to elucidate the mechanism of endothelin -2 in follicle rupture.
(b) Sulfur mustard is a continued major military threat, and has grown to become also a chemical-terrorism threat against civilians in post-9/11 era. These threats combined require approaches and strategies for 1) the measurement of injuries, and 2) prophylactic and therapeutic countermeasures. My interest is to assess sulfur mustrd-induced biological alterations such as MAPKs, PI3K/Akt pathways, NF-kB family, AP1 family and proinflammatory molecules such as COX-1/2, iNOS, MMPs, PCNA etc. and associated mechanisms in skin tissue of SKH-1 hairless mouse model for efficacy study.