Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Department of Cardiology, Jahrom University of Medical Sciences, Jahrom, Iran
Research Article
Relationship of Tumor Necrosis Factor-? 308 (G/A) Gene Polymorphism with Risk of Coronary Artery Disease in Hemodialysis Patients
Author(s): Navid Kalani*, Zeinab Fattahjahromi and Aghdas Shadmehr
Background: Prevalence and incidence of chronic renal failure is increasing and it has been considered as a threading factor in the worldwide. Cardiovascular diseases has been considered as the cause of more than half of death in hemodialysis patient. It has been shown that systemic inflammation has a key role in this issue. TNFα is a mediator cytokine of inflammation response which has a key role in pathophysiology of vascular disease caused by metabolism of lipids and obesity and insulin resistance. The aim of this study was to assess the association of polymorphism -308G/A gene TNF alpha and severity and vulnerability of cardiovascular disease in hemodialysis patient.
Materials and methods: In this case control study, we had three groups of participants; 41 hemodialysis patient with cardiovascular risk factors and 41 hemodialysis pa.. View More»
DOI:
10.35248/2155-9880.23.14.806