Journal of Depression and Anxiety
Open Access
ISSN: 2167-1044
ISSN: 2167-1044
2Graduate Institute of Medical Humanities, College of Humanities and Social Sciences,, Taipei Medical University, Taipei, Taiwan
Research Article
Banana Peel Extract (Happy Banana®) Promotes Circadian Rhythm Regulation and Sleep Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Author(s): Hsin-Chien Lee, Yung-Kai Lin, Yung-Hsiang Lin, Shu-Ting Chan and Chi-Fu Chiang*
Banana peel, a common agricultural by-product, was found to be rich in polyphenols, flavonoids, and amine compounds with potential neuroregulatory effects. This study aimed to investigate the effects of banana peel extract (Happy Banana®) on sleep-related metabolic and physiological mechanisms. Initially, the active compound Hydroxyanigorufone was identified and shown to significantly upregulate the expression of key enzymes in the tryptophan metabolic pathway in vitro. A randomized, double-blind, placebo-controlled clinical trial was subsequently conducted over four weeks, enrolling 50 subjects with self-reported sleep disturbances. The banana peel extract showed potential benefits in improving sleep quality, although it did not demonstrate a significant additional advantage over placebo. However, the results demonstrated that subjects in the banana peel group exhibited a signifi.. View More»
DOI:
10.35248/2167-1044.25.14.569