Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China
Research Article
Effects of Di-(2-Ethylhexyl) Phthalate on Oxidative Stress and Lipid Metabolism in Livers of Male Xenopus tropicalis
Author(s): Xinying Pan, Li Zheng*, Yishen Ding, Zhuo Dai, Xufeng Qi, Xiaochun Zhang, Yanbin Xu, Guangyan Xie and Qingxia Qiao
Di-(2-Ethylhexyl) Phthalate (DEHP), used as a popular plasticizer to enhance the flexibility of plastics, is a major pollutant in aquatic environments. DEHP poses severe risks to aquatic organisms since it is an endocrine-disrupting compound. To comprehensively evaluate the toxicity of DEHP on the growth and livers of male Xenopus tropicalis (X. tropicalis), sexually mature male X. tropicalis were exposed to environmentally relevant concentrations of DEHP, 0.2, 0.6, 1.8, 5.4 mg/L, for 49 days. The results showed that DEHP had a severe toxic effect on the livers of male X. tropicalis. Histopathological analysis of livers in all the DEHP-exposed groups showed changes in terms of vacuolization, loose cell cords, and an increasing amount of melanin. Large lipid droplets were markedly formed, and there were changes in the mitochondrial morphology upon DEHP exposu.. View More»
DOI:
10.35248/2161-0495.23.13.528