Journal of Research and Development
Open Access
ISSN: 2311-3278
ISSN: 2311-3278
Yogi Vemana University, India
Extended Abstract
Environmental chemistry 2020 -Citric acid Mediated One-pot Regioselective Synthesis of N-Alkylated Indazoles: An Efficient Green Strategy: Trivikram Reddy G1- Yogi Vemana University
Author(s): Trivikram Reddy
Citric acid mediated green synthetic route has been demonstrated for the regioselective synthesis of N-alkylated indazoles in good to excellent isolated yields ( ~ 78-96%) from readily available starting materials 2-methylanilines (1), NaNO2 (2) and ethyl chloroacetate (3) via diazotization, intra molecular cyclization and followed by N-alkylation in the presence of 1:1 ratio of ethanol and water in one-pot. Notably, if the substrate (1) contains – NO2 group and is reduced to – NH2 in the presence of Fe, CaCl2 in the same pot at 60-65°C for 30-40 min. The remarkable advantages of this method include cleaner reaction profile, easy to pe.. View More»