Advanced Techniques in Biology & Medicine
Open Access

Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

Biography

Toshio Doi has done his MD from Kyoto University in 1985. Currently he is working as Professor in Faculty of Medicine in Tokushima University. His research interests are Internal Medicine, Nephrology, Laboratory Medicine. Several papers of his work were published in reputed international journals. He is the member of International Society of Nephrology, American Renal Society, American Pathology Society, The Japanese Society of Internal Medicine, Japan Society of Nephrology, Japan Geriatrics Society, Japan Diabetes Society, Japan Dialysis Society, Japan Diabetic Comorbidity Society, Japan Institute for the Arts, Japanese Society of Laboratory Medicine, Vascular Medicine Society.

Publications

• Mini Review   
  A New Insight into Molecular Function of Smads Signalings in Diabetic Nephropathy
  Author(s): Hiroyuki Ono, Hideharu Abe* and Toshio Doi
  
  Diabetic Nephropathy (DN) is the leading cause of end-stage renal failure and is associated with increased morbidity and mortality compared with other causes of renal diseases. Therefore, it is important to elucidate the pathogenesis of DN and establish effective therapies for its treatment. Morphologically, DN is characterized by mesangial matrix expansion caused by the excessive deposition of extracellular matrix proteins such as type IV collagen. Prolonged exposure to hyperglycemia induces Advanced Glycation End Products (AGEs). AGE/RAGE (receptor for AGE) axis induces Bone Morphogenetic Proteins 4 (BMP4) and transforming growth factor-β (TGF-β). Both BMP4/Smad1 and TGF-β/Smad3 signaling pathways are involved in the progression of DN. In particular, Smad1 is the key signaling molecule that is directly involved in the initiation and progression of glomerulosclerosis i.. View More»
  

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