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Immunogenetics: Open Access

Immunogenetics: Open Access
Open Access

+44 1223 790975

Tiannan Wei

Department of Hematology, Shengli Clinical Medical College, Fujian Medical University, Fuzhou 350000, China

Publications
  • Research Article   
    The Clinical Value of Circulating Cell Free DNA in Multiple Myeloma
    Author(s): Tong Yang, Yun Lin*, Weimin Chen, Zhihong Wang, Tiannan Wei and Jin Shang

    Purpose: To evaluate the feasibility of the detection of circulating cell free DNA (cfDNA) and the prognostic value of cfDNA in patients with Multiple Myeloma (MM). Experimental design: All samples were screened hematopoietic malignancy associated genetic mutations from cfDNA and Bone Marrow (BM), using the Next Generation Sequencing (NGS). The mutated genetic, checked in both cfDNA and BM, were monitored at the different time points during the treatment by droplet-based digital PCR (ddPCR). Results: Three patients were included in our prospective study. Two patients detected DNMT3A mutations and one patient detected GNAQ mutation. The abundance of mutations decreased as the disease remission, and increased as the disease progresses. The detection of cfDNA has shown to predict relapses before paraprot.. View More»
    DOI: 10.35248/IGOA.22.7.174

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