Anatomy & Physiology: Current Research
Open Access
ISSN: 2161-0940
ISSN: 2161-0940
Senior Lecturer in Orthopedics, University of West Indies, Barbados
Review Article
A Review on Genetics of Intervertebral Disc Disease in Indian Perspectives
Author(s): Ravichandran Doraiswamy*, Tamara Nancoo, Andre Yusuff, Kandamaran Krishnamurthy, Pritika Kandamaran, Harshini Revanaru, Gottam Vinay and Artham Yashwanth
Degeneration of the Intervertebral Disc (IDD) is caused by a range of genetic variations. Although some have been reliably discovered in either phenotype, few are shared with polymorphisms leading to back pain. To properly understand the high heritability and how the genetic variations affect cell biology to cause IDD, more study is needed. It has long been recognized that IDD is largely heritable. New polymorphisms in a number of genes that increase the incidence of IDD and back pain have been found in recent study, in part due to the availability of agnostic approaches like genome-wide association analyses. The goal of this review is to highlight recent developments in our knowledge of the genetic causes of IDD... View More»
DOI:
10.35248/2161-0940.23.13.406