Current Synthetic and Systems Biology

Current Synthetic and Systems Biology
Open Access

ISSN: 2332-0737

Sunil Kanti Mondal

Department of Biotechnology, The University of Burdwan, India

  • Research Article   
    In Silico Study of STAT3 and its Role in MMP Mediated Metastasis
    Author(s): Sunil Kanti Mondal* and Samyabrata Mukhoty

    Metastasis is one of the major reasons for cancer associated deaths. Constitutive activation of Signal Transducer and Activator of Transcription 3(STAT3) by a variety of the factors, such as Cytokines and Growth factors within the cytoplasm, from where it is transported into the nucleus and promote the transcription of various anti-apoptotic and metastatic genes like MMP2, MMP7, MMP9, as a transcription factor and leads to several different forms of Cancers. Multiple Sequence Alignment and Jalview analysis reveals that the human STAT3 is highly conserved, with no changes along the entire length of the human STAT3 protein and maintaining close resemblance with the selected organisms. The aim of our systematic study is to identify the residues of STAT3 interacts with its nuclear transporter protein Importin and the promoter of MMP genes. So that specific inhibitor can be designe.. View More»

    Abstract PDF