Immunological Disorders and Immunotherapy
Open Access

United Kingdom

Publications

• Conference Proceeding   
  Exploration of engineered sugar molecules as vaccine candidates for Streptococcus pyogenes
  Author(s): Sowmya Ajay Castro
  
  Abstract: In 2005, the World Health Organisation released a statement calling top ten human pathogens affecting human mortality due to bacterial infection. One of the virulent organisms is Streptococcus pyogenes also known as Group A Streptococcus [GAS] is a Gram-positive bacterium causing mild strep throat to toxic shock syndrome upon prolonged infection. Annually 250,000 deaths worldwide have been reported and currently there is no licensed human vaccine available. Funded by Tenovus Scotland the aim of this project is to use the components present in GAS such as Group A Carbohydrate [GAC] specifically polyrhamnose [pRha] as a vaccine candidate. Our aim is to develop and explore the role of pRha as an immunogen by purifying pRha, which is decorated in the outer membrane vesicles of E. coli [E. colipRha]. The vaccine candidate was administered .. View More»
  

  Abstract PDF