Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
ISSN: 2157-7013
Institute of Medical Genetics, TCI GENE INC, Taipei, Taiwan
Research Article
A Multi-Herb Botanical Hydrosol Attenuates Inflammation and Fibrosis While Enhancing Mitochondrial Function in Renal Cell Models
Author(s): Yung-Kai Lin, Jian-Xin Wang, Yung-Hsiang Lin, Shu-Ting Chan, Yi-Wen Mao and Chi-Fu Chiang*
Chronic Kidney Disease (CKD) is a progressive condition characterized by inflammation, fibrosis, fluid imbalance, and mitochondrial dysfunction. While traditional medicine has long employed kidney-tonifying botanicals, their cellular mechanisms remain underexplored. This study evaluated a multi-herb botanical hydrosol formulation containing Alpinia oxyphylla Miq. and fermented extracts of Polygonatum kingianum, Euryale ferox, and Lycium chinense. Using renal epithelial cell models, we assessed its effects on inflammation, fibrosis, aquaporin regulation and mitochondrial gene activation. The hydrosol significantly inhibited Nitric Oxide (NO) production in LPS-stimulated macrophages. In IL-1β-treated HEK293 cells, it induced a time-dependent immunoregulatory response-enhancing anti-inflammatory cytokines (IL-6, IL-8, IL-10) at 6 hours, while supp.. View More»