Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
ISSN: 2167-7948
Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, Fukushima, Japan
Dr. Shinichi Suzuki is at Yokohama City University in Yokohama, Japan. His top areas of expertise are Aortic Dissection, Thoracic Aortic Aneurysm, Cardiac Tamponade, and Abdominal Aortic Aneurysm.He is having a publications in reputed journals
Original Research Article
Factors Influencing the Chemo-Sensitivity of Weekly Paclitaxel for Anaplastic Thyroid Cancer: A Clinico-Pathologic Analysis of Cases Enrolled in a Clinical Trial
Author(s): Naoyoshi Onoda*, Mitsuyoshi Hirokawa, Kennichi Kakudo, Atsuhiko Sakamoto, Kiminori Sugino, Noriaki Nakashima, Nobuyasu Suganuma, Shinichi Suzuki, Ken-ichi Ito and Iwao Sugitani
This study was conducted to identify the clinico-pathologic factors influencing the response to weekly paclitaxel treatment for Anaplastic Thyroid Cancer (ATC), a rare refractory disease. We investigated clinico-pathological factors as well as the expressions of Ki67, p53, MAD2, TLE3, ALDH1, β-tubulin, E-cadherin and vimentin among the subjects enrolled in a recent nationwide clinical trial of 56 patients with ATC in Japan. We compared the factors of eight responders and eight non-responders. The responders survived significantly longer than the non-responders (median 11.6 vs. 3.6 months, p=0.039). No significant between-group difference was found in histological subtype, TNM classification, or the expression of Ki67, p53, MAD2, TLE3, ALDH1, β-tubulin, E-cadherin or vimentin. When the patients' Prognostic Index (PI) was determined with the sum of four clinical factors, i.. View More»