Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Department of Anesthesiology, Critical Care Medicine and Pain Management, Hadassah Medical Center, Hebrew University, Jerusalem, Israel
Case Report
Severe Amlodipine and Valsartan Overdose: A Case Report Describing the Utilization of Thermodilution and Pulse Contour-Based Hemodynamic Assessment
Author(s): Shimon Firman*, Baruch M Batzofin*, Peter V van Heerden and Akiva Nachshon
Intentional overdose with either Calcium Channel Blockers or Angiotensin Receptor Blocker individually typically
does not cause severe hemodynamic instability. However, a combined overdose with agents of both classes is known
to increase the risk for hemodynamic instability, and may worsen the clinical course. We describe such an overdose,
with detailed hemodynamic monitoring using thermodilution and pulse contour analysis tracking the clinical course.
In addition, we wish to emphasize the scarce evidence supporting treatment strategies for overdose with this
combination of drugs and the need for a patient-based decision-making process in such cases... View More»
DOI:
10.35248/2161-0495.22.12.511