Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

+44 1300 500008

Shi-Ming Tu

Department of Genitourinary, Medical Oncology University of Texas MD Anderson Cancer Center, 1155 Pressler Street Houston, TX 77030-372, United States

  • Review Article   
    Application of a Successful Germ Cell Tumor Paradigm to the Challenges of Common Adult Solid Cancers
    Author(s): Shi-Ming Tu*, Matthew Campbell, Amishi Shah and Christopher J. Logothetis

    When we aspire to cure cancer, we may need to search no further than a curable cancer, such as Germ Cell Tumor of the Testis (TGCT). After all, a germ cell is a primordial stem cell. Importantly, TGCT provides a classic stem cell model of cancer that teaches us some invaluable lessons about curing other intractable solid tumors. The intrinsic intratumoral heterogeneity of TGCT alludes to its stem-ness origin and nature. Which implicates the existence of putative lethal TGCT subtypes-the identification and detection of which may further enhance the cure rate and improve the therapeutic ratio of TGCT In this Mini review, we discuss about the role of biologic insights, clinical lessons, and therapeutic strategies in drug and therapy development. We illustrate some clinical pearls and perils when it concerns drug versus therapy development in the cure and.. View More»
    DOI: 10.35248/2157-7013.21.12.301

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