Advances in Pharmacoepidemiology and Drug Safety

Internal Medicine and ICU, Square Hospitals Ltd., Dhaka, Bangladesh

Publications

• Research   
  Tigecycline in CR-Kp Associated VAP with High Dose vs. Conventional Dose: Adverse Events are the Key Superiority-determiner
  Author(s): Md Jahidul Hasan*, Raihan Rabbani, Shihan Mahmud Redwanul Huq and Sitesh Chandra Bachar
  
  Background: Multi-drug Resistant (MDR) pathogen Carbapenem-Resistance Klebsiella pneumonia (CR-Kp) associated Ventilator-Associated Pneumonia (VAP) is a serious infectious disease and tigecycline with high or conventional dose, is one of the last resort potential antibiotics for its treatment. Objective: The major objective of this study was to evaluate the key role of adverse events in preferring the better dosing option of tigecycline. Methods: Total 45 middle-aged MDR-CR-Kp associated VAP patients and treated with high (200 mg/day) and conventional dose (100 mg/day) of tigecycline (intravenous) distributed into two groups. Group-wise microbiological eradication rate, secondary infection rate, 30 days mortality rate and dose-related adverse events were analyzed and compared, accordingly. .. View more»
  

  DOI: 10.35248/2167-1052.20.9.227

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