Department of Pharmacy, Square Hospitals Ltd., Dhaka, Bangladesh
Research
Tigecycline in CR-Kp Associated VAP with High Dose vs. Conventional Dose: Adverse Events are the Key Superiority-determiner
Author(s): Md Jahidul Hasan*, Raihan Rabbani, Shihan Mahmud Redwanul Huq and Sitesh Chandra Bachar
Background: Multi-drug Resistant (MDR) pathogen Carbapenem-Resistance Klebsiella pneumonia (CR-Kp) associated Ventilator-Associated Pneumonia (VAP) is a serious infectious disease and tigecycline with high or conventional dose, is one of the last resort potential antibiotics for its treatment.
Objective: The major objective of this study was to evaluate the key role of adverse events in preferring the better dosing option of tigecycline.
Methods: Total 45 middle-aged MDR-CR-Kp associated VAP patients and treated with high (200 mg/day) and conventional dose (100 mg/day) of tigecycline (intravenous) distributed into two groups. Group-wise microbiological eradication rate, secondary infection rate, 30 days mortality rate and dose-related adverse events were analyzed and compared, accordingly.
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