Journal of Biomedical Engineering and Medical Devices
Open Access
ISSN: 2475-7586
+44 1223 790975
ISSN: 2475-7586
+44 1223 790975
Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran
Research Article
Application of Spirulina-Chitosan Nano Hydrogel for Enhanced Wound Healing through Alteration of Expression Pattern of TGF-ß and PDGF Genes
Author(s): Zahra Majedi, Armaghan Lohrasbi, Marjan Rahbar, Shadi Hajrasouliha and Sepideh Khaleghi*
Background: The wound healing process comprises of highly complex and dynamic events which allow the reestablishment
of skin's structural integrity. To overcome the drawbacks associated with this process, researchers have
been focused on the development of new therapeutics. To meet this demand, an interesting option is Chitosan
based biopolymers. This study develops and evaluates a combination of Chitosan and bioactive Spirulina microalgae,
extract hydrogel as skin serum to enhance the wound healing process.
Methods: Crude extract of dry S. platensis was prepared using three solvents (methanol, ethanol and water). Spirulina Extract-Chitosan Hydrogels (SECH) was synthesized using an ionic dilution method. SECH was characterized using
Dynamic Light Scattering (DLS) and TEM microscopy. In vitro.. View More»
DOI:
10.35248/2475-7586.21.6.185