Andrology-Open Access
Open Access
ISSN: 2167-0250
ISSN: 2167-0250
Department of Urology, Sichuan International Studies University, Chongqing, China
Research Article
CHPF Boosts Proliferation and Invasion of Clear Cell Renal Cell Carcinoma
Author(s): Yaoyu Zhang, Xiaowei Li, Shu Ran, Youguang Zhao*, Yuanshun Huang, Tingting Zhou, Qiwu Wang, Jiwen Liu, Qimin Zhang, Xiaodong Li, Taiping Leng, Yihang Luo and Shadan Li
Background: clear cell Renal Cell Carcinoma (ccRCC) is a malignant tumor most commonly seen in the urinary system, featuring quick progression, invasive behavior, frequent recrudesce, and bad prognosis, whereas Chondroitin Polymerizing Factor (CHPF) is an essential glycosyl transferase of biosynthesis involved chondroitin sulphate. But the relationship between the two has not been fully understood so far. The present research will probe into the relationship between CHPF and ccRCC.
Methods: Explore the CHPF expression level in renal ccRCC tissues through bioinformatics analysis of The Cancer Genome Atlas (TCGA) and the real-time quantitative Polymerase Chain Reaction detection system (qPCR); acquire relevant clinical data from the TCGA database and use Kaplan-Meier survival analysis to verify the relevance of CHPF expression to the clinical .. View More»