Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Saint James School of Medicine, Brampton ON, Canada
Mini Review
Mini-Review: Nitroglycerin-Induced Coronary Collapse in Myocardial Bridging - Pathophysiology and Clinical Implications
Author(s): Rose Ramsarran* and Sarah Hughes
Myocardial Bridging (MB) is a congenital anomaly in which an epicardial coronary artery, commonly the mid-Left Anterior Descending (LAD), tunnels through the myocardium rather than coursing along its surface. While typically benign, dynamic systolic compression of the bridged segment can precipitate ischemia, arrhythmias, or even infarction. Nitroglycerin, a classic anti-anginal agent, paradoxically aggravates MB-related obstruction by increasing vessel wall compliance and amplifying systolic narrowing. This mini-review summarizes current understanding of MB pathophysiology, diagnostic imaging modalities, and management strategies, highlighting the paradoxical pharmacologic effect of nitrates observed in a recent case of nitroglycerin-induced coronary collapse... View More»
DOI:
10.35248/2155-9880.25.16.982