Journal of Proteomics & Bioinformatics
Open Access

MET’s Institute of Pharmacy, Bhujbal Knowledge City, Maharashtra, India

Publications

• Research Article   
  Drug Repurposing Approach Targeting Main Protease Using HTVS and Pharmacophoric Mapping: Exceptional Reassuring Itinerary for Most Insolvent Anti-SARS-CoV-2 Drug
  Author(s): Virupaksha A. Bastikar*, Pramodkumar Gupta, Jaiprakash N. Sangshetti, Alpana V. Bastikar and Santosh S. Chhajed
  
  Coronavirus pandemic COVID 19 has caused a wide range of harm worldwide with its inception in December 2019 in Wuhan, China. Till date there is no promising drug identified for the treatment of disease. In the view of this, scientists have elucidated X-ray structures of the proteins in SARS-CoV-2 virus. These can act as probable drug targets for the designing of drugs which is urgent need. One of the main proteins of the virus is its main protease Mpro which is responsible for producing polyproteins of the virus. In this study we have used main protease as the target for drug design and repurposing for COVID-19. Two approaches were applied in order to develop a fast and effective treatment against the virus. Drug repurposing through in-silico docking analysis of existing FDA approved drugs was one method and high throughput screening of molecules from the.. View More»
  DOI: 10.35248/0974-276X.21.14.527

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