Advanced Techniques in Biology & Medicine
Open Access

Department of Biomedical Sciences, School of Science, Navrachana University, Vadodara, Gujarat, India

Publications

• Research Article   
  Single-cell RNA Sequencing of Glioblastoma Cancer Stem Cell Lines Reveals that Chromosomal Instability Leads to Disturbed Extra-cellular Matrix Organization
  Author(s): Rutvi Vaja*
  
  According to the new 2016 World Health Organization (WHO) classification of cancers of the Central Nervous System (CNS), Glioblastoma Multiforme (GBM) is the most frequent malignant tumour of the CNS. GBM contains a wide range of genetic and epigenetic changes, resulting in a large number of mutation subgroups, some of which have been shown to play a role in independent patient survival and treatment response. Despite advances in GBM treatment, patients who are diagnosed with these tumours often have a poor prognosis and a low quality of life as the disease progresses. The single-cell RNA high-throughput sequencing processed data for glioma cancer stem cells was taken from GEO-NCBI and was analyzed to find out the underlying expression differences in a single Glioma Neural Stem Cell (GSCs) and Normal Neural Stem Cell (NSCs). We have performed bioinformatics analysis on the .. View More»
  DOI: 10.35248/2379-1764.22.10.359

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